MAPT and Alzheimer disease: Representative immunohistochemical images utilizing the AT8 antibody (Figure 6a–f) and quantifications demonstrated that p-tau had overall decreased in the hippocampus and fornix in 3xTg-AD iPSC-NPCs mice compared to age-matched 3xTg-AD PBS mice (n = 7/group; FC: 1.76; p < 0.05) (Figure 6g).