TGF-β1 and TGF-β2 overexpression is an important cause for excessive scar proliferation and fibrosis, and studies have shown that the targeted reduction in TGF-β1 and TGF-β2 expression in hyperplastic scars and keloids can inhibit scar proliferation and achieve clinical therapeutic effects [29,30]. The gene discussed is TGFB2; the disease is keloid.