Multivariate Cox’s regression analysis (adjusted for tumor stage, lymph node stage, and sex) showed that GP88-negative stained ICs were an independent predictor of shorter OS (RR = 2.18; p < 0.001), DSS (RR = 2.84; p < 0.001) and RFS (RR = 2.91; p < 0.001; Table 5). Here, GRN is linked to neoplasm.