Following the treatment of cultured OPCs with IFNγ, IL1β, and TNF, cytokines that are highly expressed in the MS lesion environment, we assessed transcriptional changes by RNA sequencing (RNAseq) and observed a marked shift towards an immunomodulatory phenotype, as well as metabolic alterations that could increase vulnerability to cell stressors. This evidence concerns the gene TNF and myeloid sarcoma.