We took an in vitro approach, stimulating primary OPC cultures from WT and TNFR2−/− mice with a cocktail of Th1 cytokines (TNF/IFNγ/IL1β) known to be highly present in the MS lesion environment, and analyzing their transcriptome by RNAseq. This evidence concerns the gene TNFRSF1B and myeloid sarcoma.