The same authors reported that sex differences in tumor phenotype are dependent on differential Brd4-bound enhancer regulation of stem cell–like phenotypes in male and female, both in mice and human GBM cells; and that inhibition of Brd4 resulted in decreased in vitro clonogenicity and in vivo growth of male tumors and opposite effects on female cells and tumors [113]. The gene discussed is BRD4; the disease is neoplasm.