WWOX and early-infantile DEE: Together, WWOX deficiency in newborns suffer the disorder of sex differentiation (DSD), spinocerebellar ataxia (SCA), early infantile epileptic encephalopathy (EIEE), and WWOX-related epileptic encephalopathy (WOREE syndrome) [60,61,62,63,69,70,71,72,73].