Together, WWOX deficiency in newborns suffer the disorder of sex differentiation (DSD), spinocerebellar ataxia (SCA), early infantile epileptic encephalopathy (EIEE), and WWOX-related epileptic encephalopathy (WOREE syndrome) [60,61,62,63,69,70,71,72,73]. Here, WWOX is linked to developmental and epileptic encephalopathy, 28.