PRL and pituitary tumor: Hyperprolactinemia could be a consequence of using certain medications such as antihypertensive drugs, tricyclic antidepressants [42], or due to certain tumors such as pituitary gland tumors, including prolactin-secreting microadenoma, and prolactin-secreting macroadenoma, which leads to the destruction of the anterior pituitary gland and increased prolactin secretion, which could also be idiopathic [43].