In glioblastoma stem cells, hypoxia-inducible factor (HIF)-1α, HIF-2α [82], GLUT3 [83] and glycolysis-related enzymes, such as pyruvate dehydrogenase kinase (PDK) 1, PFKFB4, and PKM2, were upregulated [84] and the stemness properties of CSCs enhanced. The gene discussed is PFKFB4; the disease is glioblastoma.