For example, arachidonic acid 5-lipoxygenase (ALOX5), which is involved in the generation of leukotrienes (LT) from arachidonic acid (AA), and acyl-CoA synthetase very-long-chain 3 (ACSVL3/SLC27A3), which are key enzymes required for the formation of fatty acyl-CoA, was found to be required for the self-renewal of CSCs in glioblastoma [25] (Figure 4). The gene discussed is SLC27A3; the disease is glioblastoma.