As we previously reported, CSNK2A1 phosphorylates SIRT6 on Ser338 among the four phosphorylation sites of SIRT6 [10], and expression of CSNK2A1 was associated with phosphorylation of SIRT6 on Ser338 on U2OS and KHOS/NP osteosarcoma cells. Here, SIRT6 is linked to osteosarcoma.