In our lab, we examined the effect of CKD on the vascular circadian clock in two translational models: a model where early uremic vasculopathy, with no calcification, was induced in partially nephrectomized rats that were kept on a high-phosphorus diet for 8 weeks and in a second model where vascular calcification was induced by long-term uremia for 14 weeks together with the administration of a high-phosphorus diet and calcitriol [47,48]. The gene discussed is CLOCK; the disease is uremia.