On top of promoting angiogenesis, AngII/AT1R might couple to malignancy through the transactivation of EGFR, thereby hijacking downstream signaling pathways that were linked to malignant transformation, and favors cell proliferation of cancer cells by activating molecular cascades: PI3K/AKT pathway (breast cancer) [48], paired homeobox 2 (PAX2), STAT3 (signal transducer and activator of transcription 3) and JAK II (Jun activating kinase) pathways in prostate tumors [49], and RAS/RAF/ERK1/2 pathways. This evidence concerns the gene STAT3 and cancer.