(iv) JKB-121, which is an antagonist of TLR4, a receptor known to be relevant for the activation of inflammatory cytokine signaling and liver injury; this drug is now tested in a Phase II trial (NCT02442687) enrolling patients with biopsy-proven NASH and is expected to inhibit the TLR4-dependent inflammatory cascade as well as HSC activation, and the formation of collagen (TLR4 is expressed also by hepatic MFs) [149]. This evidence concerns the gene TLR4 and metabolic dysfunction-associated steatohepatitis.