HIF1A and congenital secretory chloride diarrhea 1: Starting from pioneer studies that outlined the intimate connections between hypoxia, angiogenesis and fibrogenesis [8,9,10,36,37,38,39,40], several laboratories specifically investigated the involvement of HIF-1α and HIF1 in CLD progression and we will hereafter mention only the most relevant and unequivocal ones.