OSM and metabolic dysfunction-associated steatohepatitis: In particular, we showed that OSM and OSMβR were overexpressed in either liver specimens from NASH patients as well as in liver samples from three different dietary murine protocols effective in inducing experimental NASH, including methionine- and choline-deficient (MCD) diet, choline-deficient amino acid-refined (CDAA) diet and the high fat–high fructose (HFHF) diet [114].