(ii) Experiments performed on mice genetically manipulated to have a depletion of the aryl hydrocarbon receptor nuclear translocator (ARNT or HIF-1β) in myeloid cells developed steatohepatitis when fed on a high-fat diet; this was accompanied by macrophage infiltration and expression of both M1 and M2 markers, suggesting that myeloid ARNT may have a role in the progression from NAFLD to NASH [99]. Here, ARNT is linked to metabolic dysfunction-associated steatotic liver disease.