Increased liver expression of HIF-2α was confirmed in a more limited cohort of NASH patients in a subsequent paper and the same study also provided experimental evidence for a pro-inflammatory and profibrogenic role of HIF-2α, through involvement of NF-κB activation, in a model of “hypoxic” mice (i.e., mice housed at an altitude of 4300 m for several weeks and compared to the control animals housed at an altitude of 50 m) [128]. Here, EPAS1 is linked to metabolic dysfunction-associated steatohepatitis.