NR1H4 and metabolic dysfunction-associated steatotic liver disease: Worthy of mention are at least four drugs: (i) Cenicriviroc, a double inhibitor of the CCR2/5 pathway that alone (NCT03028740) has entered into Phase III trials for NAFLD patients or it is under evaluation in combination with tropifexor, a potent farnesoid X receptor (FXR) agonist [149]; this drug is of potential interest since it can also target HSC/MFs and not only liver macrophages.