EPAS1 and fatty liver disease: Moreover, the use of mice genetically manipulated to carry hepatocyte-specific deletion of HIF-2α fed a choline-deficient L-amino acid–defined (CDAA) or a methionine/choline-deficient (MCD) diet showed that these animals exhibited a very significant improvement in terms of a reduction in parenchymal injury, liver steatosis, inflammatory response as well as of fibrosis, as compared to wild-type littermates receiving the respective control diet [126].