However, it was demonstrated that sACE2 retains not only the capability of binding the virus, forming circulating sACE2-spike protein complexes, but also its enzymatic activity [45,52,53], and that in COVID-19 patients circulating ACE2 activity is actually increased, correlates positively with disease severity and remain elevated even after disease resolution [53,118,119,120,121]. The gene discussed is ACE2; the disease is COVID-19.