Moreover, based on insulin release (88% larger AUC for insulin release in H group as compared to HS group) and calculated HOMA-IR values (125% higher in H group as compared to HS group) as surrogate measures of insulin resistance, it is apparent that insulin resistance developed by HFD feeding may be reduced by addition of a micronutrient supplement to the HFD. The gene discussed is INS; the disease is Insulin resistance.