IGF1R and myeloid sarcoma: Interestingly, let-7i, overexpressed in MS patients, was able to suppress Treg cell induction blocking the IGF1R/TGFBR1 pathway on naïve CD4+T cells, and in the group with major levels of EV-derived let-7i, the frequency of Treg cells was lower, contributing to the MS pathogenesis [62].