Furthermore, in patients with chronic obstructive pulmonary disease (COPD) activation of neutrophils, NK cells, Th17 cells, Th2 cells, Th1 cells, dendritic cells, macrophage and TNFα secreting cells can be induced by overexpression of ACE2 leading to a severe inflammatory response [39]. This evidence concerns the gene ACE2 and chronic obstructive pulmonary disease.