MLKL and viral infectious disease: Some viral infections trigger necroptosis through membrane-bound receptors (e.g., TLR3 [78,79]) or cytosolic sensors (e.g., ZBP1 [80,81,82]), and culminate with the activation and phosphorylation of mixed lineage kinase domain-like protein (MLKL), which forms a homotrimeric complex that translocates to the plasma membrane, where it forms a pore and induces cell lysis [83,84].