SERPINA12 and Insulin resistance: These results agree with other findings obtained in experiments on rats fed a high-fat diet, in which the injection of vaspin in rats’ complex led to improved insulin resistance in adipose tissue, the liver, and skeletal muscle by enhanced transduction of the IRS/PI3K/Akt/GLUT2 pathway, which simultaneously inhibited the IκBα/NFκB-signaling pathway [73].