TNF and myeloid sarcoma: When we stratified MS patients according to the cortical lesion load, we found significantly higher levels of TNF (p < 0.001), sTNF-R1 (p < 0.001) and sTNF-R2 (p < 0.01) in MS-High patients (with high cortical lesion loads) with respect to MS-Low ones (with low cortical lesion loads) (Figure 4).