We propose that the herein observed alterations in AChE and mAChR-M1 expression and aggravation of ischemia induced synaptic dysfunction in the dentate gyrus elicited by miRNA 132/212 deletion might help in the establishment of a link between miRNA 132/212, cholinergic signaling and ischemia associated cognitive impairment. This evidence concerns the gene ACHE and ischemia.