WNK2 and infection: Viral proteins with RGD motifs promote infection by binding integrin heterodimers including αVβ1, αVβ3, αVβ5, αVβ6, αVβ8, α5β1, α8β1 and αIIbβ3 [54] activating transducing pathways involving phosphatidylinositol-3 kinase (PI-3K) or mitogen-activated protein kinase (MAPK), which promote virus entry and infection of the host cell [3].