MAPT and Parkinson disease: As a follow-up, it would be interesting to distinguish non-proliferative senescent astrocytes/microglia from proliferative reactive astrocytes or microglia [5]; further, it can be an intriguing but promising approach to apply senolytics to the α-syn PFF injected mouse model to see whether the pharmacological intervention would be sufficient to halt or reverse Lewy-body like protein aggregation-induced PD pathology, since its possibility was suggested in tau-dependent pathology [22,23,24] as well as renal regeneration [35].