Since our focus was not to assess the effects on SASP by α-syn PFF, we did not assess all the SASP-related cytokines, but we found in qRT-PCR that IL-8 was up-regulated by α-syn PFF exposure in both cortex-derived astrocytes and microglia culture (data not shown), as reported in human PD post-mortem SNpc [7]. This evidence concerns the gene CXCL8 and Parkinson disease.