Our WB analysis revealed that the levels of Lamin B1 (Figure 7A,B), HMGB1 (Figure 7A,C) and SATB1 (Figure 7A,D) were substantially reduced, whereas the p21 level was significantly increased (Figure 7A,F) in the midbrain of human PD postmortem tissues compared to age- and gender-matched controls. The gene discussed is SATB1; the disease is Parkinson disease.