Additionally, by using MC-specific Pla2g3 KO mice as well as KitW-sh mice adoptively transferred with Pla2g3−/− BMMCs, we addressed the roles of MC-derived sPLA2-III in irritant contact dermatitis (ICD), an acute inflammation, and contact hypersensitivity (CHS), a Th1-dependent delayed-type allergic response. The gene discussed is PLA2G3; the disease is contact dermatitis.