N1 neutrophils exert an anti-tumor effect through the production of hypochlorous acid (HOCl), reactive oxygen species (ROS), tumor necrosis factor (TNF)-α, and nitric oxide (NO) and promote an immunogenic microenvironment by inhibiting interleukin (IL)-17 production and exhibiting increased antibody-dependent cell cytotoxicity (ADCC) [60]. Here, TNF is linked to neoplasm.