IL6 and neoplasm: To the contrary, N2 neutrophils support tumor growth through the production of vascular endothelial growth factor (VEGF), IL-1β, IL-6, and IL-17, promote an immune-suppressive microenvironment by recruiting Treg, and favor the metastatic process by inducing neutrophil extracellular trap (NET) formation [60], a type of neutrophil death leading to the release of DNA–histone complexes and proteins to form net-like structures.