For example, quercetin, a dietary flavonoid, can reduce RTEC senescence in renal fibrosis via SIRT1/PINK1/mitophagy axis [31], while liraglutide, a glucagon-like peptide-1 receptor agonist, can improve mitochondrial homeostasis in heart injury through the identical signaling axis [32]. This evidence concerns the gene SIRT1 and renal fibrosis.