The mutation RhoA-G17V (a missense mutation leading to the change of the amino acid glycine on position 17 to valine) is common in CD4+ T-cells in lymphoma [103] and is associated with autoimmunity, hyper-responsiveness of T-cells, and excessive TCR signaling via the Rho-GEF Vav1 [104]. Here, VAV1 is linked to Autoimmunity.