RAC1 and malignant pleural mesothelioma: Moreover, it has been shown that both PFKFB3 ablation and inhibition with PFK158 trigger late endosome formation in malignant pleural mesothelioma by increasing the interaction of Rac1 with Rab7 [59], where Rab7 plays an important role in the final maturation of late autophagic vacuoles [60].