PTEN and neoplasm: Moreover, PFKFB3 expression can be regulated by oncogenes like hypoxia-inducible factor 1-alpha (HIF-1a), RAS, mesenchymal epithelial transition (MET), phosphoinositide 3-kinases (PI3K/Akt), and phosphatase and tensin homolog (PTEN) to provide metabolic control of tumor development [21,22,23,24].