Of note, ganglioside dynamics are affected indirectly in SPG11 (for Spastic Paraplegia Gene 11), a frequent autosomal recessive subtype of HSP [15], through accumulation of GM2 species in lysosomes [16], and directly in SPG26, another HSP form, because of the loss of function of one key enzyme of ganglioside metabolism, B4GALNT1 [17]. Here, SPG11 is linked to hereditary spastic paraplegia.