VCP and amyotrophic lateral sclerosis: Interestingly, the gene encoding for the protein valosin-containing protein (VCP), an interactor of strumpellin, can cause several neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Charcot–Marie–Tooth (CMT) disease and notably HSP, when mutated [73,74,75,78,79].