OS cells secrete factors, such as bone morphogenic proteins (BMPs), RANKL, and IL-6, which can stimulate osteoclastogenesis, which leads to increased osteolysis and to the consequent release of TGFβ, insulin-like growth factors (IGFs), fibroblast growth factors (FGFs), and others facilitating OS tumor growth from the bone matrix [58]. The gene discussed is IL6; the disease is neoplasm.