In a different study, the same group, in order to study the regulatory effect of the TME on T cell function in OS, analyzed the peripheral blood (PB) and tumor-infiltrating T cells (TILs) in patients with localized OS disease and found that the frequency of CD163+ TAMs is directly correlated with that of suppressed TIM-3+ PD-1+ T cells in tumor lesions [18]. The gene discussed is HAVCR2; the disease is neoplasm.