For example, macrophages are generally dichotomized into M1 inflammatory/anti-tumor and M2 pro-tumoral/pro-angiogenic macrophages, and CD4 T cells can be Th1, Th2, Th17, T regulatory cells, or other newly identified CD4 T cell subsets that may have either pro- or anti-tumor characteristics [10,11]. The gene discussed is CD4; the disease is neoplasm.