EZH2 and SMYD2 mainly exert their regulatory functions in cilia assembly, and inhibition of either of them promotes ciliogenesis and slows down the cell cycle, while Aur A and HDAC6 promote cilia disassembly and cell cycle progression, and inhibition of Aur A and HDAC6 decreases cilia disassembly and delays the cell cycle, leading to the same outcomes in cancers and ciliopathies. Here, HDAC6 is linked to ciliopathy.