EZH2 encodes the methyltransferase unit of polycomb repressive complex 2 (PRC2), and exhibits its role in driving metastatic melanoma formation by mediating primary cilia deconstruction through its canonical histone methylation mark H3K27me3 on the cilia loci, and inhibiting the expression of diverse ciliary genes [76] (Figure 3B). This evidence concerns the gene EZH2 and melanoma.