PI3K/AKT (pro-survival pathway) activation [54,55,56], activations of immunosuppressive cells such as Tregs (regulatory T cells) and TAMs (tumor-associated macrophages) promoting (CSC) survival, blocking anti-tumorigenic immune cell recruitment [57], impairing the proliferation and activation of T cells [57] are all a crucial (ECM) mechanism of actions. The gene discussed is AKT1; the disease is neoplasm.