On the other hand, however, TRPC1/4-mediated Ca2+ influx has a protective effect in hypoxia-induced pulmonary arterial hypertension by maintaining autophagic responses [83], suggesting that the effect of TRPC1/4-mediated Ca2+ influx depends on the specific physiological or pathophysiological context, respectively. This evidence concerns the gene TRPC1 and pulmonary arterial hypertension.