TRPC1 and pulmonary arterial hypertension: In contrast to that, TRPC1/4 is suggested to be protective in hypoxia-induced pulmonary arterial hypertension [83], where activation of nuclear factor-kappa B (NF-κB) and increased Galectin-3 expression shifts cellular response towards apoptosis by inactivation of TRPC1/4 and resulting suppression of autophagy [83].