SPP1 and breast neoplasm: A proinflammatory gene signature has been identified in CAFs of breast tumors and consists of two chemokines that are chemoattractants for neutrophils and macrophages (CXCL1, and CXCL2), the proinflammatory cytokines IL-1β and IL-6, the proangiogenic gene CYR61, COX-2, and osteopontin (OPN), which is known to affect inflammation, angiogenesis and metastasis [60,143,145].