IL6 and neoplasm: The high CAA intratumoral adipocyte content has been shown to be enriched in inflammation-related gene sets such as TNF-α signaling via NF-κB, IL-6/JAK/STAT3 signaling and inflammatory response, and thus a high amount of intratumoral adipokines associated with inflammation that promote angiogenesis, invasion, metastases, and tumor progression [93].