Ruffell et al. [27] found myeloid-lineage cells including macrophages (CD14hiCD11b+HLADR+), mast cells (FcεR1α+CD117+CD11b−CD49d+) and neutrophils (CD15+CD11b+CD49d−) were more evident in normal tissues (both cancer-adjacent and prophylactic mastectomy), which contrasted with that in breast cancer where the density of immune infiltrates was substantially increased and consisted of infiltrates dominated by T lymphocytes (CD3ε+), with minor populations of natural killer cells (CD3ε−CD56+NKG2D+) and B lymphocytes (CD19/20+HLA-DR+CD3−). This evidence concerns the gene CD3E and breast carcinoma.