The proinflammatory changes have been well summarized by Van Kruijsdijk et al. [51] who observed that obesity is strongly associated with changes in the physiological function of adipose tissue, increased levels of leptin, plasminogen activator inhibitor-1, endogenous sex steroids, and chronic inflammation, which are involved in carcinogenesis and cancer progression. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.