LGR5 and cancer: Thus, the interrelationship between the signaling of GOF mutp53 and chromatin modifiers, such as PRC2 and EZH2, and the molecular mechanisms underlying the generation of the cancer stem cell markers CD44, CD133, LGR5, and ALDH, should be clarified, and other signaling pathways, such as Wnt–β-catenin and FOXA1 should be elucidated.