Mutant p53 activates lipid metabolism in tumors; moreover, it binds to and activates a series of transcription factors, the sterol regulatory element-binding proteins, and induces the expression of many genes in the mevalonate pathway, which leads to the disruption of breast cancer cell architecture in a 3D culture model and contributes to increased proliferation, survival, invasion, and metastasis [107]. Here, TP53 is linked to breast carcinoma.