Twenty-one (63.3%) participants with nonfunctioning adenoma had hypopituitarism: 11 (52.4%) participants had cortisol deficits, 3 (14.3%) had FSH deficits, 3 (14.3%) had undergone thyroid agent treatment, and 4 (19.0%) had diabetes insipidus. The gene discussed is BRD2; the disease is adenoma.