CIITA and colorectal cancer: Since the HLA class II transactivator CIITA has been shown to be involved in chromatin remodeling [61] and the HLA class II surface antigens could be induced in some melanoma cell lines, it was analyzed whether the lack of HLA class II surface antigen is due to the methylation of the CIITA promoter, as already shown for gastric and colorectal cancer, for example [62].