Since BRD4 plays an important role in recruiting the P-TEFb (CDK9/Cyclin T) complex to super enhancers thereby promoting active gene transcription [65], and since BRD4 plays a role in the development of lung cancers [66], we examined if drugs targeting this bromodomain protein improve the efficacy of CDK9 inhibitors. The gene discussed is BRD4; the disease is lung cancer.