Importantly, combining APLN-KO and APLN-KD had synergistic anti-angiogenic effects and reduced pathological vascularization in a GBM model to a level comparable to (or even lower than in) healthy brain regions; infusion of the Apelin-13 peptide was able to rescue the APLN loss-of-function phenotype [44]. This evidence concerns the gene APLN and glioblastoma.