VHL and clear cell renal carcinoma: We took advantage of the identified mutation based on the use of the clear-cell renal carcinoma 786-0 cells transfected with either empty (EV), WT VHL, or VHL-R167Q encoding vectors (Figure 1A) and showed that this mutation, despite the induction of VHL (Figure 1B), still induced HIF-2α expression in a marginal manner, as assessed by western blot, and that it was most likely associated with a decreased degradation of HIF-2 (Figure 1B).