In the Cox proportional hazard regression models, heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), C8A, CHMP6, latent transforming growth factor β-binding protein 4 (LTBP4), SPR, NCEH1, mitochondrial ribosomal protein S23 (MRPS23), polymerase delta interacting protein 2 (POLDIP2), and Williams–Beuren syndrome chromosome region 16 (WBSCR16) were significantly associated with the prognosis of ACC (Figure 6). The gene discussed is SPR; the disease is adrenal cortex carcinoma.