Collectively, our data suggest that IH induces migration and EMT-TF and CSC-TF expression in melanoma cells stimulated with PSPC1 and TGFβ, which highlights the relevance of hypoxemia in inducing a tumor microenvironment that facilitates a synergism by means of PSPC1, switching TGFβ activation that is associated with tumor progression by EMT-TF and CSC-TF. Here, PSPC1 is linked to neoplasm.