A significant number of studies concentrating their attention on extrapolating from pediatric to adult ALL acknowledged molecular mutations more frequently found with advancing age, such as IKZF1 gene deletions, JAK mutations or CRLF2 gene alterations/overexpression, immunoglobulin heavy chain (IGH) translocations, and iAMP21 [3,25,35,39,40,41]. The gene discussed is IKZF1; the disease is acute lymphoblastic leukemia.