RB1 and oropharynx cancer: While HPV-positive oropharyngeal cancer has low or no common genetic abnormalities, such as p53 mutation, and is directly associated with contamination of high risk HPV subtypes, HPV-negative oropharyngeal cancer is closely related with smoking and excessive alcohol consumption and demonstrates commonly activated mutation of oncogenes such as EGFR, RAS, PI3 kinase or functional loss of tumor suppressor genes such as p53, p16, and RB1 or both [2].