The highly connected nodes (hubs) are cyclin D1, endothelin 1 (endothelin pathway), matrix metallopeptidase 2 (implicated in protein or RNA binding), fibroblast growth factor 2 (cell survival), interleukin-8, interleukin-6 (inflammation marker), G protein subunit beta 3 (involved in α-adrenergic signaling), nitric oxide synthase 3 (involved in cardiovascular disorders and hypertension). The gene discussed is NOS3; the disease is cardiovascular disorder.