Based on Beclin 1, LC3II/LC3I, and p62 expression results, being considered the main factors for the assessment of autophagy levels and progression, we can state that EP is capable of inducing apoptosis inhibiting the autophagy mechanism induced by chemotherapy with MMC on human hypopharyngeal carcinoma (FaDu) and carcinoma of the tongue (CAL 27) cell lines. Here, SQSTM1 is linked to hypopharyngeal carcinoma.