PRAME and melanoma: Table 3 summarizes the PRAME IHC results in SDN. One of 35 SDN showed diffuse PRAME staining (2.9%). This was a superficial atypical melanocytic proliferation of uncertain significance (SAMPUS), in which the final diagnostic interpretation favored a SDN, but an early-stage melanoma could not be excluded. A reexcision with 5 mm margins was recommended and follow-up of 121 months remained uneventful (Figure 5). Of the remaining 21 SDN with PRAME immunoreactivity, 81.0% showed weaker PRAME staining in the dermal than in the epidermal portion (Figure 6).