Beside the clinical stage, a significant association between CLL-related autoimmune complications and other negative prognostic parameters, such as high lymphocyte count, high β2-microglobulin or LDH level, increased CD38 or ZAP-70 expression, adverse FISH [i.e., del(17p) or del(11q)], or unmutated IGHV has been observed in different cohorts [149,150,151,152,153,154,155,156,157,158]. The gene discussed is HLA-G; the disease is B-cell chronic lymphocytic leukemia.