NLCs induce apoptosis-resistance in tumor cells [102], and elevated serum levels of NLCs-secreted cytokines in patients with CLL correlate with poor prognostic factors (i.e., Rai stage III or IV, elevated LDH and/or β2-microglobulin) and have a negative impact on OS [103,104]. This evidence concerns the gene HLA-G and B-cell chronic lymphocytic leukemia.