We have recently shown that extracellular acidosis directly activates the NF-kB inflammatory family of transcription factors and thus the secretion of NF-kB-related cytokines, chemokines, and growth factors by the osteosarcoma-associated stromal compartment formed by osteoblasts, MSC, and CAF [32,58]. Here, NFKB1 is linked to osteosarcoma.