In the former case, the RAB39A-RXRB axis has been shown to have a prominent role in the development of osteosarcoma stemness and aggressiveness at a pH of 6.5 [145], while in the latter case, the pH-dependent accumulation of S1P seems to be of paramount importance in the survival and growth potential of osteosarcoma xenografts [82]. The gene discussed is RXRB; the disease is osteosarcoma.