Regardless of the source of acidosis, after a few hours, incubation with a pHe 6.8 activates RelA, RelB, or NF-kB that, in turn, induce the expression of the inflammatory cytokines IL-8 and IL-6 and enhances cancer stemness (formation of spheroids and expression of the stemness-related markers oct4 or Nanog [32]). The gene discussed is NFKB1; the disease is cancer.