The anarchic formation of new vessels that provide O2 and nutrients needed by actively proliferating cells is induced by tumour cells through the release of pro-angiogenic factors, such as vascular endothelial growth factor (VEGF) and interleukin 8 (IL-8) [98], or through the stabilisation of HIF-1 that are promoted by extracellular acidosis [99,100]. The gene discussed is CXCL8; the disease is neoplasm.