As an example, in osteosarcoma, the voltage-gated potassium channel Kv1.3, transient receptor potential cation channel subfamily M member 8 (TRPM8), and piezo type mechanosensitive ion channel component 1 (Piezo1) are among the most expressed pH-sensitive ion channels and correlate with tumour progression [88,89,90]. The gene discussed is PIEZO1; the disease is osteosarcoma.