In osteosarcoma, we demonstrated the pH-dependent activation (at a pH of 6.5) of a stress-regulated switch that promotes the recruitment of the TNF-receptor-associated factors/cellular inhibitor of apoptosis protein 1 (TRAF/cIAP) complexes, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway [95]. Here, NFKB1 is linked to osteosarcoma.