SEC16B and cancer: Specifically, single nucleotide variation (SNV) of OBSCN is the most frequently predicted gene alteration, while SNV of SEC16B, IRAK3, TNPO2, LIN9, and RAB31 constituted 9%, 5%, 5%, 4%, and 2% of genetic alterations in the TCGA cohort of the hub cancers (Figure 5B–D).