Our earlier mechanistic study indicated that inhibition of numerous oncogenic molecules and signaling pathways such as Wnt/β-catenin, Hippo/YAP1, PI3K/mTOR, exosomal Mir-21/STAT3/β-Catenin, JAK2/STAT3/JARID1B, tumor necrosis factor (TNF)-α, nuclear factor (NF)-κB, matrix metalloproteinases (MMPs), and FLICE inhibitory protein (FLIP) were associated with the anti-cancer activity of this bioactive phytochemical [15,17,18,20,22]. This evidence concerns the gene TNF and cancer.