In this preceding study, we found that HLA-DR+ CTLs were mainly present inside the tumor microenvironment; produced high levels of cytotoxicity-related molecules, such as IFN-γ, Granzyme B, and Perforin; were negatively correlated with immunosuppressive features of the tumor milieu; and were reflected systemically [9]. This evidence concerns the gene GZMB and neoplasm.